Morpholine, a six-membered heterocycle
containing one nitrogen and one oxygen atom, is a moiety of great
significance.It possesses both amine as well as
ether functional groups and is extensively used in many pharmaceutical
as well industrial preparations.Meanwhile, as a fairly strong base
with pKa of 8.7, its widely used as an intermediate in many organic
syntheses[1].
Morpholine containing drugs are of high therapeutic value.Its wide array of
pharmacological activity includes anti-depressant[1], bronchodilator[1], anti-autoimmune
diseases[2],anti-HIV[3],antitubercular[4-5]and anticancer[1,6]. |
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[1] European Journal of Medicinal Chemistry
(2019), 167, 324-356.
[2] ChemMedChem (2019), 14, 1917-1932.
[3] ACS Medicinal Chemistry Letters (2020), Ahead of Print.
[4]
Cell Chemical Biology (2020), 27, 172-185.
[5] European Journal of Medicinal Chemistry (2020), 190,
Article 112106.
[6] Bioorganic & Medicinal Chemistry Letters (2020), 30,
Article 127076.
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