, Defluoro O-Methyl Dolutegravir , - yabo88体育官网下载

：纯度：No Data Available CAS：

英文名称：Defluoro O-Methyl Dolutegravir

品牌：TRC

规格	目录价格	上海	会员价格	数量
100mg	请询价	0	一般3-5周，以TRC实际库存为准	请询价	- +

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基本信息

英文名称

Defluoro O-Methyl Dolutegravir

分子式

C21 H22 F N3 O5

纯度

No Data Available

Standards; Pharmaceutical/API Drug Impurities/Metabolites;

Defluoro O-Methyl Dolutegravir is an intermediate in the synthesis of Defluoro Dolutegravir (D228715) which is an impurity of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.

Kobayashi, M. et al. Antimicrob Agents Chemother., 55, 813 (2011); Garrido, C. et al.: Antiviral, Res., 90, 164 (2011); Lenz, J.C.C. et al.: Exp. Opin. Invest. Drugs, 20, 537 (2011);

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